The Epidemiology of Koala Retrovirus
نویسندگان
چکیده
منابع مشابه
Transspecies transmission of the endogenous koala retrovirus.
The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis. Here we characterize a KoRV newly isolated from an animal in a German zoo and show infection of human and rat cell lines in vitro and of rats in vivo, using immunological and PCR methods fo...
متن کاملKoala Retrovirus in Free-Ranging Populations — Prevalence
The prevalence of koala retrovirus (KoRV) provirus (DNA) and the average number of proviral insertions per cell vary in different free-ranging koala (Phascolarctos cinereus) populations across Australia. Populations in the northern states of Queensland and New South Wales have 100% proviral prevalence and mean proviral copy number of 140–165 per cell. In contrast, the proviral prevalence in the...
متن کاملHybridization Capture Reveals Evolution and Conservation across the Entire Koala Retrovirus Genome
The koala retrovirus (KoRV) is the only retrovirus known to be in the midst of invading the germ line of its host species. Hybridization capture and next generation sequencing were used on modern and museum DNA samples of koala (Phascolarctos cinereus) to examine ca. 130 years of evolution across the full KoRV genome. Overall, the entire proviral genome appeared to be conserved across time in s...
متن کاملIdentification of a novel subgroup of Koala retrovirus from Koalas in Japanese zoos.
We identified a new subgroup of koala retrovirus (KoRV), named KoRV-J, which utilizes thiamine transport protein 1 as a receptor instead of the Pit-1 receptor used by KoRV (KoRV-A). By subgroup-specific PCR, KoRV-J and KoRV-A were detected in 67.5 and 100% of koalas originating from koalas from northern Australia, respectively. Altogether, our results indicate that the invasion of the koala pop...
متن کاملSequence variation of koala retrovirus transmembrane protein p15E among koalas from different geographic regions.
The koala retrovirus (KoRV), which is transitioning from an exogenous to an endogenous form, has been associated with high mortality in koalas. For other retroviruses, the envelope protein p15E has been considered a candidate for vaccine development. We therefore examined proviral sequence variation of KoRV p15E in a captive Queensland and three wild southern Australian koalas. We generated 163...
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ژورنال
عنوان ژورنال: Journal of Veterinary Epidemiology
سال: 2011
ISSN: 1881-2562,1343-2583
DOI: 10.2743/jve.15.1